Making the rounds in the blog-o-sphere™ these days is Wil Shipley's talk and slides of his advice on programming and running a business. A great (and funny) presentation, it's directed towards students but actually enjoyable by all. Though I didn't directly have the benefit of Wil's advice when starting Karelia, I have since appreciated his tidbits of wisdom.
I just wanted to put in a plug for the session at last year's O'Reilly Mac OS X Conference (in which Wil, I, and several Mac developers participated), which is available in audio format, courtesy of Niall Kennedy. Just in case anybody missed it the first time around.